By Naga Chalasani, Gyongyi Szabo
This quantity is the 1st textual content to concisely but comprehensively disguise advancements for either alcoholic and nonalcoholic fatty liver ailment in an equipped type. features of those illnesses coated within the publication comprise international epidemiology and hazard components, pathogenesis, animal types, hepatic and extra-hepatic malignancies, therapy types, and present and rising treatments.
Written via specialists within the box, Alcoholic and Non-Alcoholic Fatty Liver sickness: Bench to Bedside is a useful source for gastroenterologists, pathologists, and hepatologists who deal with sufferers with alcoholic and nonalcoholic fatty liver disease.
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Additional resources for Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside
The genetic predisposition of NAFLD is very also interesting and will be discussed in detail in subsequent chapters. As noted previously, it is important to mention that NAFLD in the USA may also be present in nonobese patients. In fact, this type of NAFLD may be more common in Asian countries. 7 % in the obese and overweight individuals . Furthermore, the clinical proﬁle of lean patients with NAFLD is also different where the patients tended to be younger, female, and having a decreased likelihood of having insulin resistance and hypercholesterolemia .
The study design—characteristics of the population sample and the methodology for diagnosis of NAFLD— also differs signiﬁcantly across studies. Despite these, the available data provide an assessment of NAFLD epidemiology in Asia and the Middle East with fair precision and depict the changes happening over time. 2). A more detailed workup, including measurement of liver stiffness—(continued attenuation parameter based quantiﬁcation of liver fat, CT scan and liver biopsy) has been carried out in a few of these studies for better precision and characterization of liver disease status.
Exome-wide association study identiﬁes a Tm6sf2 variant that confers susceptibility to 112. 113. 114. 115. 116. 117. 118. 119. nonalcoholic fatty liver disease. Nat Genet. 2014; 46:352–6. He S, Mcphaul C, Li JZ, Garuti R, Kinch L, Grishin NV, Cohen JC, Hobbs HH. A sequence variation (I148M) in Pnpla3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem. 2010;285:6706–15. Pingitore P, Pirazzi C, Mancina RM, Motta BM, Indiveri C, Pujia A, Montalcini T, Hedfalk K, Romeo S.
Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside by Naga Chalasani, Gyongyi Szabo